Flavivirus nonstructural protein 2B (NS2B) is a transmembrane protein that functions as a cofactor for viral NS3 protease. The cytoplasmic region (amino acids 51-95) alone of NS2B is sufficient for the NS3 protease activity, whereas the role of transmembrane domains (TMDs) remains obscure. The Research Group of Flavivirus Infection, led by Prof. Bo Zhang demonstrates for the first time, that fl...
One of the most common protein post-translational modifications is N-linked glycosylation. N-linked glycosylation is important in proper protein folding, transit to the cell surface and secretion, in a protein, as well as cell context dependent manner. The normal cellular prion protein, PrP, is a widely expressed, highly conserved, glycosylphosphatidylinositol (GPI)-anchored cell surface glyco...
By cooperation with Shenzhen Entry-Exit Inspection and Quarantine Bureau, scientists from WIV have isolated one Zika virus strain, which will assist scientists study the transmission pattern of the virus while provide a foundation for the invention of reagent and vaccine.
Tuberculosis, an ancient, yet re-emerging infectious disease, is responsible for more deaths than almost all other infectious diseases, and the vaccine, drugs and diagnostic tests currently in use are limiting the effectiveness of global efforts to prevent and control TB. The BCG vaccine, the only licensed TB vaccine, has now been in use for almost one hundred years; however, it provides only l...
