RNA viruses encode a unique class of RNA-dependent RNA polymerases (RdRPs) to carry out their fully RNA-based genome replication and transcription. Although the chemical nature of nucleotide addition is essentially shared by all nucleic acid polymerases, the structural and mechanistic details taken by each polymerase class differ to various extents. The research group led by Prof. Peng Gong in ...
Atherosclerosis is a leading cause of death globally. Targeted imaging and therapeutics are desirable for the detection and treatment of the disease. Recently, the research group led by Prof. Zongqiang Cui in WIV developed trifunctional Simian virus 40 (SV40)-based nanoparticles for in vivo targeting and imaging of atherosclerotic plaques. These novel trifunctional SV40-based nanoparticles enca...
A new research report appearing on August 30th 2016 in Cell Reports dissects the cellular role of WhiB6, one of the WhiB redox sensor family proteins, in virulence and intracellular survival of pathogenic mycobacteria, according to researchers from the Center for Emerging Infectious Diseases, Wuhan Institute of Virology (WIV), Chinese Academy of Sciences (CAS).
RgsA is a phylogenetically conserved small regulatory RNA (sRNA) in Pseudomonas species. This sRNA has been shown to be directly controlled by the major stationary phase and stress sigma factor σS (RpoS), and also indirectly regulated by the GacS/GacA two-component system. However, the role and the regulatory targets of this sRNA remain unclear. Here, the research group led by Professor Shiyun...
