Since H5N6 avian influenza virus first emerged in China in 2013, it has caused more than ten human deaths in China, which poses potential risks to human health. In order to further understand the evolutionary behavior of H5N6 prior to its emergence in humans, the research group led by Prof. CUI Jie from Wuhan Institute of Virology of the Chinese Academy of Sciences developed the studies on the ...
Macrophages are one of the major targets of human immunodeficiency virus (HIV-1), but how the virus enters the macrophages is still poorly understood. In present study, Prof. CUI Zongqiang from Wuhan Institute of Virology of the Chinese Academy of Sciences, Prof. ZHANG Xian’en from Institute of Biophysics of the Chinese Academy of Sciences, and Prof. WU Yuntao from George Mason University have...
In present study, the research group led by Prof. ZHANG Bo from Wuhan Institute of Virology of the Chinese Academy of Sciences and the research team led by Prof. QIN Chengfeng from Institute of Microbiology and Epidemiology of the Academy of Military Medical Sciences made an important breakthrough in the pathogenic mechanism of arthropod-borne flaviviruses. By using in vivo bioluminescence imag...
The nucleotide addition cycle of nucleic acid polymerases includes two major events: the pre-chemistry active site closure leading to the addition of one nucleotide to the product chain; the post-chemistry translocation step moving the polymerase active site one position downstream on its template. In viral RNA-dependent RNA polymerases (RdRPs), structural and biochemical evidences suggest that...
